Cape Girardeau Regional Airport is served by 0 airlines, flying from/to 0 destinationsLongest flight from Cape Girardeau Regional Airport is Cape Girardeau to 🇺🇸 Chicago (ORD), which takes around 1 hour and 40 minutes. On an airline like Contour Airlines. More info on this flight route (CGI-ORD).Shortest flight from Cape Girardeau Regional Airport is Cape Girardeau to 🇺🇸 Chicago (ORD), which takes around 1 hour and 40 minutes. On an airline like Contour Airlines. More info on this flight route (CGI-ORD).