Des Moines International Airport is served by 9 airlines, flying from/to 16 destinationsLongest flight from Des Moines International Airport is Des Moines to 🇺🇸 Santa Ana (SNA), which takes around 3 hours and 55 minutes. On an airline like Allegiant Air. More info on this flight route (DSM-SNA).Shortest flight from Des Moines International Airport is Des Moines to 🇺🇸 Omaha (OMA), which takes around 30 minutes. On an airline like Netjets Aviation. More info on this flight route (DSM-OMA).