Florence Regional Airport is served by 2 airlines, flying from/to 3 destinationsLongest flight from Florence Regional Airport is Florence to 🇺🇸 Charlotte (CLT), which takes around 1 hour and 15 minutes. On an airline like American Airlines. More info on this flight route (FLO-CLT).Shortest flight from Florence Regional Airport is Florence to 🇺🇸 Charlotte (CLT), which takes around 1 hour and 15 minutes. On an airline like American Airlines. More info on this flight route (FLO-CLT).