La Crosse Regional Airport is served by 4 airlines, flying from/to 4 destinationsLongest flight from La Crosse Regional Airport is La Crosse to 🇺🇸 Chicago (ORD), which takes around 1 hour and 5 minutes. On an airline like Air Wisconsin. More info on this flight route (LSE-ORD).Shortest flight from La Crosse Regional Airport is La Crosse to 🇺🇸 Minneapolis (MSP), which takes around 45 minutes. On an airline like Bemidji Airlines. More info on this flight route (LSE-MSP).