Louisville Muhammad Ali International Airport is served by 27 airlines, flying from/to 129 destinationsLongest flight from Louisville Muhammad Ali International Airport is Louisville to 🇦🇪 Dubai (DXB), which takes around 13 hours and 15 minutes. On an airline like UPS Airlines. More info on this flight route (SDF-DXB).Shortest flight from Louisville Muhammad Ali International Airport is Louisville to 🇺🇸 Columbus (LCK), which takes around 40 minutes. On an airline like UPS Airlines. More info on this flight route (SDF-LCK).