John Wayne/Orange County Airport is served by 27 airlines, flying from/to 48 destinationsLongest flight from John Wayne/Orange County Airport is Santa Ana to 🇺🇸 New York City (JFK), which takes around 5 hours and 25 minutes. On an airline like American Airlines. More info on this flight route (SNA-JFK).Shortest flight from John Wayne/Orange County Airport is Santa Ana to 🇺🇸 Van Nuys (VNY), which takes around 15 minutes. On an airline like Netjets Aviation. More info on this flight route (SNA-VNY).